Drug General Information
Drug ID	D02UHP
Former ID	DNC009363
Drug Name	6,7-dibromoquinoline-5,8-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529691]
Structure		Download 2D MOL 3D MOL
Formula	C9H3Br2NO2
Canonical SMILES	C1=CC2=C(C(=O)C(=C(C2=O)Br)Br)N=C1
InChI	1S/C9H3Br2NO2/c10-5-6(11)9(14)7-4(8(5)13)2-1-3-12-7/h1-3H
InChIKey	CPZKOUMVYNIHQE-UHFFFAOYSA-N
PubChem Compound ID	255964
Target and Pathway
Target(s)	M-phase inducer phosphatase 2	Target Info	Inhibitor	[529691]
KEGG Pathway	MAPK signaling pathway
	Cell cycle
	Progesterone-mediated oocyte maturation
	MicroRNAs in cancer
NetPath Pathway	IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Wnt Signaling Pathway
Pathway Interaction Database	PLK1 signaling events
	FOXM1 transcription factor network
	p38 signaling mediated by MAPKAP kinases
	Aurora A signaling
Reactome	Cyclin B2 mediated events
	Cyclin A/B1 associated events during G2/M transition
	Cyclin A:Cdk2-associated events at S phase entry
WikiPathways	Senescence and Autophagy in Cancer
	MAPK Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Mitotic G2-G2/M phases
	Cell Cycle
References
Ref 529691	Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
Ref 529691	Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.

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