Drug Information

Drug General Information
Drug ID
D02VCK
Former ID
DIB013477
Drug Name
FLUPAROXAN
Synonyms
BAN; Fluparoxan < Rec INN; GR-50360A (HCl); (3aS,9aS)-5-Fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]benzodioxino[2,3-c]pyrrole
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Discontinued in Phase 3 [540696], [544705]
Structure
Download
2D MOL

3D MOL
Formula
C10H10FNO2
InChI
InChI=1S/C10H10FNO2/c11-6-2-1-3-7-10(6)14-9-5-12-4-8(9)13-7/h1-3,8-9,12H,4-5H2/t8-,9-/m0/s1
InChIKey
XSOUHEXVEOQRKJ-IUCAKERBSA-N
CAS Number
CAS 105182-45-4
PubChem Compound ID
72036
PubChem Substance ID
8194980, 15120869, 15322348, 43128268, 52885447, 57318490, 103064655, 103080961, 104351928, 117510551, 129734967, 131284535, 132555468, 134222494, 135030005, 135650272, 137185874, 162221780, 162775840, 179149527, 198969230, 226485094
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [528251]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 540696(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 41).
Ref 544705Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000678)
Ref 528251The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist. Br J Pharmacol. 1991 Apr;102(4):887-95.

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