Drug Information

Drug General Information
Drug ID
D02VJX
Former ID
DIB018917
Drug Name
AVE 0991
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540950]
Structure
Download
2D MOL
Formula
C29H32N4O5S2
InChI
InChI=1S/C29H32N4O5S2/c1-5-30-29(35)32-40(36,37)28-24(16-23(39-28)15-19(2)3)21-13-11-20(12-14-21)17-33-25(18-34)27(38-4)31-26(33)22-9-7-6-8-10-22/h6-14,16,18-19H,5,15,17H2,1-4H3,(H2,30,32,35)
InChIKey
QTOZBSNPDCWHPV-UHFFFAOYSA-N
PubChem Compound ID
9851724
PubChem Substance ID
14935751, 24147332, 45274048, 77667637, 125647294, 131309658, 142400440, 172649931, 175426352, 178102215, 198951655, 210275350, 210280998, 223395787, 240007867, 242060197, 245715644, 252477740
Target and Pathway
Target(s) Proto-oncogene Mas Target Info Agonist [527181]
KEGG Pathway Neuroactive ligand-receptor interaction
Renin-angiotensin system
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
References
Ref 540950(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5579).
Ref 527181Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44(4):490-6. Epub 2004 Aug 23.

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