Drug Information

Drug General Information
Drug ID
D02WGN
Former ID
DIB009180
Drug Name
YM-114
Synonyms
KAE-393; (R)-5-(2,3-Dihydro-1H-indol-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride
Drug Type
Small molecular drug
Indication Nausea [ICD10:R11] Discontinued in Phase 2 [545300]
Structure
Download
2D MOL

3D MOL
Formula
C16H18ClN3O
Canonical SMILES
C1CC2=C(CC1C(=O)N3CCC4=CC=CC=C43)NC=N2.Cl
InChI
1S/C16H17N3O.ClH/c20-16(12-5-6-13-14(9-12)18-10-17-13)19-8-7-11-3-1-2-4-15(11)19;/h1-4,10,12H,5-9H2,(H,17,18);1H/t12-;/m1./s1
InChIKey
GZXONPGTMHLBKQ-UTONKHPSSA-N
CAS Number
CAS 132036-91-0
PubChem Compound ID
132963
PubChem Substance ID
14751867, 29310980, 57344323, 75136272, 104378648, 135089075, 227275266
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Antagonist [534150], [551871]
KEGG Pathway Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 545300Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002741)
Ref 534150Effect of serotonin (5-HT)3-receptor antagonists YM060, YM114 (KAE-393), ondansetron and granisetron on 5-HT4 receptors and gastric emptying in rodents. Jpn J Pharmacol. 1995 Nov;69(3):205-14.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.