Drug Information

Drug General Information
Drug ID
D02XOK
Former ID
DNCL003097
Drug Name
Levomilnacipran
Drug Type
Small molecular drug
Indication Fibromyalgia [ICD9: 729.1; ICD10:M79.7] Approved [530677], [542458]
Company
Forest Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C15H22N2O
InChI
InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1
InChIKey
GJJFMKBJSRMPLA-DZGCQCFKSA-N
CAS Number
CAS 96847-55-1
PubChem Compound ID
6917779
PubChem Substance ID
16010452, 23950786, 43529203, 50872352, 103316413, 103940908, 114786948, 127962304, 135626792, 137129347, 139020085, 160658357, 175271225, 175427154, 178104007, 179149463, 198967714, 227628532, 250148599
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Modulator [530677]
Sodium-dependent serotonin transporter Target Info Modulator [530677]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 542458(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7435).
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.

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