Drug General Information
Drug ID	D02ZPM
Former ID	DIB012993
Drug Name	Anpirtoline
Synonyms	D-16949
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[528148]
Company	ASTA Medica AG
Structure		Download 2D MOL 3D MOL
Formula	C10H13ClN2S
Canonical SMILES	n1c(SC2CCNCC2)cccc1Cl
PubChem Compound ID	65854
Target and Pathway
Target(s)	5-hydroxytryptamine 1B receptor	Target Info	Modulator	[528148]
	5-hydroxytryptamine 1A receptor	Target Info	Modulator	[528148]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	GPCR downstream signaling
References
Ref 528148	Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl Med Biol. 2006 Apr;33(3):325-32. Epub 2006 Mar 9.
Ref 528148	Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl Med Biol. 2006 Apr;33(3):325-32. Epub 2006 Mar 9.

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