Drug Information

Drug General Information
Drug ID
D02ZSU
Former ID
DIB016750
Drug Name
NS-49
Synonyms
Garomefrine hydrochloride; ABT-232; PNO-49B
Drug Type
Small molecular drug
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Discontinued in Phase 2 [468041], [545984]
Company
Nippon Shinyaku Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C9H13FN2O3S
InChI
InChI=1S/C9H13FN2O3S/c1-16(14,15)12-6-2-3-8(10)7(4-6)9(13)5-11/h2-4,9,12-13H,5,11H2,1H3/t9-/m0/s1
InChIKey
XYLJNMCMDOOJRW-VIFPVBQESA-N
PubChem Compound ID
9838763
PubChem Substance ID
15122145, 15196652, 24137476, 44936851, 79504432, 103269914, 129759148, 135650746, 163641571, 198988480, 224979721, 228142194, 242055755
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Modulator [525556]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 468041(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 481).
Ref 545984Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005693)
Ref 525556Pharmacokinetics of NS-49, a phenethylamine class alpha 1A-adrenoceptor agonist. 3rd communication: metabolism in rats, rabbits, dogs and monkeys, and effects on hepatic drug-metabolizing enzyme activities in rats after repeated administration. Arzneimittelforschung. 1999 Jul;49(7):612-7.

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