Drug General Information
Drug ID	D03ABH
Former ID	DIB006118
Drug Name	Deriglidole
Synonyms	SL-84.0418; SL-84.0714; SL-84.0715
Drug Type	Small molecular drug
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Discontinued in Phase 2	[544511]
Company	Synthelabo
Structure		Download 2D MOL 3D MOL
Formula	C16H21N3
Canonical SMILES	N12C(C3=NCCN3)(Cc3c1c(CC2)ccc3)CCC
CAS Number	CAS 122830-14-2
PubChem Compound ID	65945
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[534576]
	Alpha-1D adrenergic receptor	Target Info	Modulator	[534576]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, Other
References
Ref 544511	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000010)
Ref 534576	Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole. Life Sci. 1998;62(9):839-52.

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