Drug Information

Drug General Information
Drug ID
D03CEZ
Former ID
DNC012676
Drug Name
AGROCLAVINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532683]
Structure
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2D MOL

3D MOL
Formula
C16H18N2
Canonical SMILES
CC1=CC2C(CC3=CNC4=CC=CC2=C34)N(C1)C
InChI
1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,13,15,17H,7,9H2,1-2H3/t13-,15-/m1/s1
InChIKey
XJOOMMHNYOJWCZ-UKRRQHHQSA-N
PubChem Compound ID
73484
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [532683]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [532683]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 532683J Med Chem. 1988 Aug;31(8):1512-9.Ergolines as selective 5-HT1 agonists.
Ref 532683J Med Chem. 1988 Aug;31(8):1512-9.Ergolines as selective 5-HT1 agonists.

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