Drug Information

Drug General Information
Drug ID
D03DJL
Former ID
DCL000846
Drug Name
Indacaterol
Synonyms
QAB-149; Indacaterol (USAN/INN); 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one; 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Approved [531783], [542479]
Company
Novartis
Structure
Download
2D MOL

3D MOL
Formula
C24H28N2O3
InChI
InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)/t22-/m0/s1
InChIKey
QZZUEBNBZAPZLX-QFIPXVFZSA-N
CAS Number
CAS 312753-06-3
PubChem Compound ID
6918554
PubChem Substance ID
14805326, 15126362, 17194957, 43529924, 50944939, 96025998, 103751149, 104152520, 114788160, 126665799, 134339311, 135252041, 136946521, 137248550, 137261964, 140383548, 144116077, 152258566, 152343993, 160645865, 160647401, 162011653, 162197410, 164227489, 164777215, 172919100, 174528841, 175266645, 175426936, 187051758, 189561508, 198991946, 223601296, 223667503, 223701040, 224342928, 226432041, 241382349, 246478537, 247088325, 251916861, 251918100, 252063646, 252110200, 252436254
SuperDrug ATC ID
R03AC18
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [536223], [537130]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 542479(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7455).
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
Ref 537130Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94.

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