Drug Information

Drug General Information
Drug ID
D03DJR
Former ID
DIB020665
Drug Name
D-65476
Synonyms
bis(1H-2-indolyl)methanone deriv. 52; D-65476
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526272]
Structure
Download
2D MOL
Formula
C21H18N2O3
InChI
InChI=1S/C21H18N2O3/c1-2-5-20(24)26-15-8-9-17-14(10-15)12-19(23-17)21(25)18-11-13-6-3-4-7-16(13)22-18/h3-4,6-12,22-23H,2,5H2,1H3
InChIKey
CZDUJGOCEPWCNA-UHFFFAOYSA-N
PubChem Compound ID
5330548
PubChem Substance ID
8036171, 11062289, 16148097, 26759341, 39303162, 47276676, 53790470, 53800597, 79668649, 85787182, 99302737, 103165727, 113915929, 121363820, 124896622, 135340661, 163687512, 175607423, 178102640, 179236136, 208264818
Target and Pathway
Target(s) Alpha platelet-derived growth factor receptor Target Info Inhibitor [526272]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling network
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
Hair Follicle Development: Organogenesis (Part 2 of 3)
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Signaling Pathways in Glioblastoma
Signaling by PDGF
Angiogenesis
References
Ref 526272Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. J Med Chem. 2002 Feb 28;45(5):1002-18.
Ref 526272Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. J Med Chem. 2002 Feb 28;45(5):1002-18.

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