Drug General Information
Drug ID	D03DVJ
Former ID	DIB002878
Drug Name	Propylhexedrine
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Approved	[551871]
Structure		Download 2D MOL 3D MOL
Formula	C10H22ClN
Canonical SMILES	CNC(C)CC1CCCCC1
InChI	1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3
InChIKey	JCRIVQIOJSSCQD-UHFFFAOYSA-N
PubChem Compound ID	102541
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[533622], [551871]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533622	Airway compromise and delayed death following attempted central vein injection of propylhexedrine. J Emerg Med. 1994 Nov-Dec;12(6):795-7.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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