Drug General Information
Drug ID	D03EFD
Former ID	DIB011163
Drug Name	KT-95
Synonyms	KT-90
Indication	Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]		Terminated	[546410]
Company	Toho Chemical Industry Co
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@]123c4c5O[C@H]1[C@H](SC(=O)C)CC[C@H]2[C@H](N(CC1CC1)<br />CC3)Cc4ccc5OC(=O)C
Target and Pathway
Target(s)	Kappa-type opioid receptor	Target Info	Modulator	[543763]
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Opioid prodynorphin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546410	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007966)
Ref 543763	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318).

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