Drug Information

Drug General Information
Drug ID
D03ESA
Former ID
DNC001136
Drug Name
P-MPPI
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541881]
Structure
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2D MOL

3D MOL
Formula
C25H27IN4O2
InChI
InChI=1S/C25H27IN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3
InChIKey
DHMLNZRDVQLQBB-UHFFFAOYSA-N
PubChem Compound ID
4658
PubChem Substance ID
5350526, 8152864, 11111416, 15457156, 29223747, 47291336, 50064511, 57322382, 74412359, 85209986, 90341259, 103202467, 103812228, 103943525, 104307048, 117512152, 124750065, 126407958, 127735591, 134224965, 135078110, 135650409, 135697708, 179293691, 184591578, 228731902, 252159849
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [538050], [538142]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 541881(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 68).
Ref 538050Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603.
Ref 538142p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. Eur J Pharmacol. 1998 Oct 23;359(2-3):185-90.

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