Drug Information

Drug General Information
Drug ID
D03FKF
Former ID
DIB020800
Drug Name
repinotan
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543318]
Structure
Download
2D MOL
Formula
C21H24N2O4S
InChI
InChI=1S/C21H24N2O4S/c24-21-18-8-2-4-10-20(18)28(25,26)23(21)14-6-5-13-22-15-17-12-11-16-7-1-3-9-19(16)27-17/h1-4,7-10,17,22H,5-6,11-15H2/t17-/m1/s1
InChIKey
YGYBFMRFXNDIPO-QGZVFWFLSA-N
PubChem Compound ID
198757
PubChem Substance ID
10263022, 14903639, 14903640, 33518394, 50501990, 57399163, 113468514, 123096754, 129794336, 134339744, 135142362, 135650895, 137249442, 140233804, 162223539, 179149941, 198975668, 223800757, 226973463
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [534575]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 543318(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 95).
Ref 534575Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. J Pharmacol Exp Ther. 1998 Mar;284(3):1082-94.

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