Drug General Information
Drug ID	D03GRA
Former ID	DNC003167
Drug Name	(R)-Mevalonate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540044]
Structure		Download 2D MOL 3D MOL
Formula	C6H11O4-
InChI	InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1
InChIKey	KJTLQQUUPVSXIM-ZCFIWIBFSA-M
CAS Number	CAS 150-97-0
PubChem Compound ID	5288798
PubChem Substance ID	2951, 7888884, 14717736, 39321128, 46508035, 50669434, 61013392, 113872836, 135651556, 137139211, 160966633, 162779470, 223808188
Target and Pathway
Target(s)	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Target Info	Inhibitor	[551393]
BioCyc Pathway	Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
	Superpathway of cholesterol biosynthesis
	Mevalonate pathway
KEGG Pathway	Terpenoid backbone biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	AMPK signaling pathway
	Bile secretion
NetPath Pathway	IL5 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	TSH Signaling Pathway
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBF and miR33 in cholesterol and lipid homeostasis
	Integrated Breast Cancer Pathway
	SREBP signalling
	Cholesterol Biosynthesis
References
Ref 540044	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3042).
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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