Drug Information

Drug General Information
Drug ID
D03ITI
Former ID
DNC006590
Drug Name
Sunepitron
Synonyms
Sunepitron hydrochloride; SUNEPITRON HYDROCHLORIDE; (7S,9aS)-7-(2,5-Dioxopyrrolidin-1-ylmethyl)-2-(2-pyrimidinyl)octahydro-1H-pyrido[1,2-a]pyrazine hydrochloride; (7S,9aS)-1-[2-(2-Pyrimidinyl)perhydropyrido[1,2-a]pyrazin-7-ylmethyl]pyrrolidine-2,5-dione hydrochloride; Sunepitron hydrochloride < Prop INNM; USAN >; CP-93393 (free base); CP-93393-1; 131831-03-3
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 3 [545699]
Unspecified Investigative [528210]
Structure
Download
2D MOL

3D MOL
Formula
C17H24ClN5O2
Canonical SMILES
C1CC2CN(CCN2CC1CN3C(=O)CCC3=O)C4=NC=CC=N4
InChI
1S/C17H23N5O2/c23-15-4-5-16(24)22(15)11-13-2-3-14-12-21(9-8-20(14)10-13)17-18-6-1-7-19-17/h1,6-7,13-14H,2-5,8-12H2
InChIKey
UXWBIYCPUVWKHP-UHFFFAOYSA-N
CAS Number
CAS 148408-65-5
PubChem Compound ID
6918176
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Inhibitor [528210]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [528210]
Alpha-1A adrenergic receptor Target Info Inhibitor [528210]
Alpha-1D adrenergic receptor Target Info Inhibitor [528210]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04024:cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretionhsa04020:Calcium signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP58:Monoamine GPCRs
Endothelin Pathways
AMPK SignalingWP58:Monoamine GPCRs
GPCRs, Other
References
Ref 528210J Med Chem. 2006 Jun 1;49(11):3116-35.An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
Ref 545699Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004255)
Ref 528210J Med Chem. 2006 Jun 1;49(11):3116-35.An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.

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