Drug General Information
Drug ID	D03JSS
Former ID	DIB011479
Drug Name	Tidembersat
Synonyms	SB-218842
Drug Type	Small molecular drug
Indication	Migraine [ICD9: 346; ICD10:G43]		Discontinued in Phase 1	[546798]
Company	SmithKline Beecham plc
Structure		Download 2D MOL 3D MOL
Formula	C20H19F2NO4
Canonical SMILES	[C@@H]1(c2c(OC([C@@H]1O)(C)C)ccc(c2)C(=O)C)NC(=O)c1cc(c<br />c(c1)F)F
CAS Number	CAS 175013-73-7
PubChem Compound ID	170378
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Antagonist	[551730]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546798	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010348)
Ref 551730	Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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