Drug Information

Drug General Information
Drug ID
D03KIA
Former ID
DNC000403
Drug Name
Cerivastatin
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Approved [539962], [545021]
Structure
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2D MOL

3D MOL
Formula
C26H34FNO5
InChI
InChI=1S/C26H34FNO5/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32)/b11-10+/t19-,20-/m1/s1
InChIKey
SEERZIQQUAZTOL-ANMDKAQQSA-N
CAS Number
CAS 145599-86-6
PubChem Compound ID
446156
PubChem Substance ID
10167, 822164, 7978896, 10299839, 10852026, 14809054, 14858094, 36888654, 46505877, 46518451, 48415746, 50067077, 50070698, 50728881, 51091965, 56312092, 56313141, 56313595, 92308707, 93166525, 93578306, 103541455, 104635877, 126681828, 134339434, 134339836, 135259857, 135650063, 137002687, 142742086, 160963785, 164788182, 164807583, 176484089, 179116613, 184546299, 198953954, 223659548, 223898596, 226406536, 226406537, 241035409, 252347182
SuperDrug ATC ID
C10AA06
SuperDrug CAS ID
cas=145599866
Target and Pathway
Target(s) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [535663]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretion
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol Biosynthesis
References
Ref 539962(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2950).
Ref 545021Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001906)
Ref 535663HMG-CoA reductase inhibitor has protective effects against stroke events in stroke-prone spontaneously hypertensive rats. Stroke. 2003 Jan;34(1):157-63.

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