Drug Information

Drug General Information
Drug ID
D03MHA
Former ID
DIB019878
Drug Name
FR260010
Synonyms
FR-260010; FR 260010
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540200]
Structure
Download
2D MOL
Formula
C22H19N5
InChI
InChI=1S/C22H19N5/c1-15-12-27(14-25-15)18-7-4-6-17(11-18)26-22-20-10-9-16-5-2-3-8-19(16)21(20)23-13-24-22/h2-8,11-14H,9-10H2,1H3,(H,23,24,26)
InChIKey
LFKNMCJSJZOQJF-UHFFFAOYSA-N
PubChem Compound ID
9968450
PubChem Substance ID
14945506, 24234201, 46065021, 80784158, 85227155, 124974655, 178100281, 223828480, 232774291, 246904319
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Antagonist [528502]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 540200(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3223).
Ref 528502Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. Eur J Pharmacol. 2006 Dec 28;553(1-3):171-84. Epub 2006 Sep 28.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.