Drug General Information
Drug ID	D03NWV
Former ID	DNC011932
Drug Name	1-(2-Ethoxy-phenyl)-piperazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533134]
Structure		Download 2D MOL 3D MOL
Formula	C12H18N2O
Canonical SMILES	CCOC1=CC=CC=C1N2CCNCC2
InChI	1S/C12H18N2O/c1-2-15-12-6-4-3-5-11(12)14-9-7-13-8-10-14/h3-6,13H,2,7-10H2,1H3
InChIKey	FBQIUSDQWOLCNY-UHFFFAOYSA-N
PubChem Compound ID	83357
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[533134]
	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[533134]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	GPCR downstream signaling
References
Ref 533134	J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Ref 533134	J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.

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