Drug Information

Drug General Information
Drug ID
D03RCP
Former ID
DIB012840
Drug Name
NM-135
Synonyms
Glucocorticoid, Nissin Food
Indication Dermatitis [ICD9: 692.9; ICD10:L20-L30] Discontinued in Phase 2 [546950]
Company
Nissin Foods Holdings Co Ltd
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[C@]12([C@@]3([C@H]([C@H]4[C@@]([C@H]([C@@H](C4)C)C(=O)<br />CO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)COC(=O)c4ccc(cc4)C<br />)OC(=O)c4ccc(cc4)C)OC(=O)c4ccc(cc4)C)OC(=O)c4ccc(cc4)C)<br />(C[C@@H]3O)C)C[C@@H](C1=CC(=O)C=C2)F)F)C
CAS Number
CAS 169453-84-3
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Modulator [534820]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 546950Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011462)
Ref 534820Local anti-inflammatory activity and systemic side effects of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model. Jpn J Pharmacol. 1998 Dec;78(4):505-9.

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