Drug General Information
Drug ID	D03RGP
Former ID	DNC011406
Drug Name	(R,S)-AMPA
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529714]
Structure		Download 2D MOL 3D MOL
Formula	C7H10N2O4
Canonical SMILES	CC1=C(C(=O)NO1)CC(C(=O)O)N
InChI	1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
InChIKey	UUDAMDVQRQNNHZ-UHFFFAOYSA-N
PubChem Compound ID	1221
Target and Pathway
Target(s)	Glutamate receptor AMPA subtype	Target Info	Inhibitor	[529714]
	Glutamate receptor, ionotropic kainate 1	Target Info	Inhibitor	[529714]
	Glutamate receptor 1	Target Info	Inhibitor	[529714]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapsehsa04024:cAMP signaling pathway
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Dopaminergic synapse
	Long-term depression
	Amyotrophic lateral sclerosis (ALS)
	Amphetamine addiction
	Nicotine addiction
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathwayP00037:Ionotropic glutamate receptor pathway
Pathway Interaction Database	EPHB forward signaling
Reactome	COPII (Coat Protein 2) Mediated Vesicle Transport
	Trafficking of AMPA receptors
	Trafficking of GluR2-containing AMPA receptors
	Unblocking of NMDA receptor, glutamate binding and activation
	Cargo concentration in the ER
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP666:Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Amyotrophic lateral sclerosis (ALS)
	BDNF signaling pathway
References
Ref 529714	J Med Chem. 2008 Oct 23;51(20):6614-8. Epub 2008 Sep 24.1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Ref 529714	J Med Chem. 2008 Oct 23;51(20):6614-8. Epub 2008 Sep 24.1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.

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