Drug Information

Drug General Information
Drug ID
D03RMB
Former ID
DNC013665
Drug Name
2-{[R-(-)-Apomorphine-2'-oxy]ethoxy}-ethanol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529349]
Structure
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2D MOL

3D MOL
Formula
C21H25NO5
Canonical SMILES
CN1CCC2=C3C1CC4=C(C3=CC(=C2)OCCOCCO)C(=C(C=C4)O)O
InChI
1S/C21H25NO5/c1-22-5-4-14-10-15(27-9-8-26-7-6-23)12-16-19(14)17(22)11-13-2-3-18(24)21(25)20(13)16/h2-3,10,12,17,23-25H,4-9,11H2,1H3/t17-/m1/s1
InChIKey
LUIRUBNQVJTQKP-QGZVFWFLSA-N
PubChem Compound ID
44567596
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [529349]
D(2) dopamine receptor Target Info Inhibitor [529349]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04015:Rap1 signaling pathway
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 529349Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. Epub 2008 Feb 15.Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines.
Ref 529349Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. Epub 2008 Feb 15.Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines.

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