Drug General Information
Drug ID	D03RRJ
Former ID	DNC000803
Drug Name	Iodine-131-tositumomab
Drug Type	Antibody
Indication	Discovery agent		Phase 2	[523216]
Structure		Download 2D MOL 3D MOL
Formula	C44H39ClN8O5
PubChem Compound ID	9918746
Target and Pathway
Target(s)	B-lymphocyte antigen CD20	Target Info		[535062], [536721]
KEGG Pathway	Hematopoietic cell lineage
References
Ref 523216	ClinicalTrials.gov (NCT01224821) Dosimetry/Validation Study of 131Iodine-Anti B1 (Murine) Radioimmunotherapy for Chemotherapy Refractory Low Grade B Cell Lymphomas and Low Grade Lymphomas That Have Transformed to Higher Grade Histologies. U.S. National Institutes of Health.
Ref 535062	A phase I/II trial of iodine-131-tositumomab (anti-CD20), etoposide, cyclophosphamide, and autologous stem cell transplantation for relapsed B-cell lymphomas. Blood. 2000 Nov 1;96(9):2934-42.
Ref 536721	Rituximab blocks binding of radiolabeled anti-CD20 antibodies (Ab) but not radiolabeled anti-CD45 Ab. Blood. 2008 Aug 1;112(3):830-5. Epub 2008 May 23.

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