Drug General Information
Drug ID
D03SAM
Former ID
DNC000012
Drug Name
(R)-alpha-methylhistamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538749]
Structure
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2D MOL

3D MOL

Formula
C6H11N3
InChI
InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1
InChIKey
XNQIOISZPFVUFG-RXMQYKEDSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histamine H3 receptor Target Info Agonist [535262], [536039]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538749(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1236).
Ref 535262Azomethine prodrugs of (R)-alpha-methylhistamine, a highly potent and selective histamine H3-receptor agonist. Curr Med Chem. 2001 Sep;8(11):1329-40.
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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