Drug General Information
Drug ID	D03SWH
Former ID	DIB001834
Drug Name	PNU-142633
Drug Type	Small molecular drug
Indication	Migraine [ICD9: 346; ICD10:G43]		Discontinued in Phase 2	[547202]
Company	Pharmacia & Upjohn Inc
Structure		Download 2D MOL 3D MOL
Formula	C24H30N4O3
Canonical SMILES	N1(c2ccc(C(=O)N)cc2)CCN(CC[C@H]2c3c(cc(C(=O)NC)cc3)CCO2<br />)CC1
CAS Number	CAS 187665-65-2
PubChem Compound ID	9845148
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Agonist	[526906], [551730]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547202	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013927)
Ref 526906	Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):220-7. Epub 2003 Dec 12.
Ref 551730	Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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