Drug Information

Drug General Information
Drug ID
D03TBJ
Former ID
DIB013247
Drug Name
GRT-6005
Synonyms
Centrally-acting nociceptin agonist analgesic (oral liquid, pain/diabetic neuropathy), Grunenthal
Drug Type
Small molecular drug
Indication Diabetic neuropathy [ICD9: 250, 250.6, 356.0, 356.8; ICD10:E11.40] Phase 3 [532969]
Company
Forest laboratories
Structure
Download
2D MOL

3D MOL
Formula
C24H27FN2O
Canonical SMILES
CN(C)C1(CCC2(CC1)C3=C(CCO2)C4=C(N3)C=CC(=C4)F)C5=CC=CC=<br />C5
InChI
1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3
InChIKey
CSMVOZKEWSOFER-UHFFFAOYSA-N
PubChem Compound ID
11848225
PubChem Substance ID
17161025, 23905162, 29276917, 78850597, 134416830, 134428069, 134433132, 137617153, 138184419, 141601065, 162108872, 163620953, 163686275, 164136012, 172232529, 172821449, 185990510, 198982507, 226518787, 226873156, 235376985, 239168083, 244746916, 249312211, 249736839, 252151321, 252811244
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Modulator [532969]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 532969Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist. Br J Anaesth. 2015 Mar;114(3):364-6.
Ref 532969Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist. Br J Anaesth. 2015 Mar;114(3):364-6.

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