Drug Information

Drug General Information
Drug ID
D03VGR
Former ID
DIB020543
Drug Name
N-methyl LTC4
Synonyms
N-methyl-leukotriene C4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541366]
Structure
Download
2D MOL
Formula
C31H49N3O9S
InChI
InChI=1S/C31H49N3O9S/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-26(25(35)16-15-18-28(37)38)44-22-24(30(41)33-21-29(39)40)34-27(36)20-19-23(32-2)31(42)43/h7-8,10-14,17,23-26,32,35H,3-6,9,15-16,18-22H2,1-2H3,(H,33,41)(H,34,36)(H,37,38)(H,39,40)(H,42,43)/b8-7-,11-10-,13-12+,17-14+/t23?,24?,25-,26+/m0/s1
InChIKey
FPLBRCJNODNRQZ-LZHUJPGBSA-N
PubChem Compound ID
73755185
PubChem Substance ID
178102815
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Agonist [531263]
Leukotriene CysLT2 receptor Target Info Agonist [531263]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 541366(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6194).
Ref 531263Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT?? agonist, N-methyl-leukotriene C?? in calcium reporter and beta arrestin assays. Mol Pharmacol. 2011 Feb;79(2):270-8.

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