Drug General Information
Drug ID	D03XYG
Former ID	DNC012258
Drug Name	1-Methyl-1,3-dihydro-indol-2-one
Indication	Discovery agent		Investigative	[526055]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[526055]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[526055]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04020:Calcium signaling pathway
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, Other
References
Ref 526055	Bioorg Med Chem Lett. 2001 May 7;11(9):1229-31.Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.
Ref 526055	Bioorg Med Chem Lett. 2001 May 7;11(9):1229-31.Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.

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