Drug Information

Drug General Information
Drug ID
D03YBH
Former ID
DIB020246
Drug Name
LTD4
Synonyms
leukotriene D4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540310]
Structure
Download
2D MOL
Formula
C25H40N2O6S
InChI
InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20?,21-,22+/m0/s1
InChIKey
YEESKJGWJFYOOK-LDDGIIIKSA-N
PubChem Compound ID
6435286
PubChem Substance ID
11621374, 15504876, 26754797, 26759050, 43028624, 48258956, 49973403, 53787561, 56310711, 56312017, 56313563, 57367453, 76371580, 104046425, 114548095, 126524720, 127315583, 127315584, 127315585, 127315586, 127315587, 127315588, 127315589, 127315590, 127315591, 127315592, 127315593, 127315594, 127315595, 127315596, 127315597, 127315598, 127315599, 127315600, 127315601, 127315602, 127315603, 127315604, 135011469, 135651513, 163687799, 178100418, 230238786, 242320133
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Agonist [525572]
GPR17 Target Info Agonist [528446]
Leukotriene CysLT2 receptor Target Info Agonist [525921]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 540310(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3353).
Ref 525572Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol. 1999 Sep;56(3):657-63.
Ref 525921Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec;58(6):1601-8.
Ref 528446The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. Epub 2006 Sep 21.

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