Drug Information

Drug General Information
Drug ID
D03YPJ
Former ID
DNC001281
Drug Name
SB 206553
Drug Type
Small molecular drug
Indication Discovery agent Terminated [539189], [546078]
Structure
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2D MOL

3D MOL
Formula
C17H16N4O
InChI
InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
InChIKey
QJQORSLQNXDVGE-UHFFFAOYSA-N
CAS Number
CAS 214745-43-4
PubChem Compound ID
5163
PubChem Substance ID
13905, 866556, 5591037, 7979278, 8153174, 11111766, 11114169, 14898053, 29224225, 47736664, 50104925, 57322635, 75242555, 85209908, 85789041, 90340847, 92729639, 103221386, 103847082, 103956180, 104308451, 117537767, 124750284, 124881377, 124881378, 129032563, 134338690, 134340487, 134340488, 134348480, 135650985, 137161672, 142945656, 162223686, 163146104, 174006270, 179150021, 196394253, 223259267, 223440902, 227667615
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Antagonist [535165]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 539189(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 189).
Ref 546078Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006211)
Ref 535165Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze. Braz J Med Biol Res. 2001 May;34(5):675-82.

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