Drug Information

Drug General Information
Drug ID
D03ZHB
Former ID
DNC008151
Drug Name
5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529148]
Structure
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2D MOL

3D MOL
Formula
C10H12ClN3
Canonical SMILES
CCC1C2=C(C=CC=C2Cl)NC(=N1)N
InChI
1S/C10H12ClN3/c1-2-7-9-6(11)4-3-5-8(9)14-10(12)13-7/h3-5,7H,2H2,1H3,(H3,12,13,14)
InChIKey
MICIQKQOEFSTDP-UHFFFAOYSA-N
PubChem Compound ID
44455973
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 5A receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 7 receptor Target Info Inhibitor [529148]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapsehsa04014:Ras signaling pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
GPCRs, Other
References
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.

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