Drug General Information
Drug ID	D03ZVD
Former ID	DIB003405
Drug Name	KW-4490
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[547542]
Company	Kyowa Hakko Kogyo Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	CAMP-specific 3',5'-cyclic phosphodiesterase 4A	Target Info	Inhibitor	[529433]
	Type IV phosphodiesterase	Target Info	Inhibitor	[529433]
	CAMP-specific 3',5'-cyclic phosphodiesterase 4B	Target Info	Inhibitor	[529433]
KEGG Pathway	Purine metabolism
	cAMP signaling pathway
	Morphine addictionhsa00230:Purine metabolism
	Morphine addiction
NetPath Pathway	IL5 Signaling Pathway
	IL2 Signaling Pathway
PathWhiz Pathway	Purine Metabolism
Reactome	DARPP-32 events
	G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
	G alpha (s) signalling events
WikiPathways	G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	TSH signaling pathwayWP35:G Protein Signaling Pathways
	Nuclear Receptors Meta-Pathway
	Opioid Signalling
References
Ref 547542	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017153)
Ref 529433	Pharmacokinetics and metabolism of KW-4490, a selective phosphodiesterase 4 inhibitor: difference in excretion of KW-4490 and acylglucuronide metabolites between rats and cynomolgus monkeys. Xenobiotica. 2008 May;38(5):511-26.

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