TTD | Drug: D03ZWL

Drug General Information
Drug ID	D03ZWL
Former ID	DNC014562
Drug Name	L-740093
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[543272]
Structure		Download 2D MOL 3D MOL
Formula	C26H31N5O2
InChI	InChI=1S/C26H31N5O2/c1-17-6-5-7-20(14-17)27-26(33)29-23-25(32)30(2)22-9-4-3-8-21(22)24(28-23)31-15-18-10-11-19(16-31)13-12-18/h3-9,14,18-19,23H,10-13,15-16H2,1-2H3,(H2,27,29,33)/t18?,19?,23-/m0/s1
InChIKey	QYERABWMFRRINX-XWEVFREBSA-N
PubChem Compound ID	132980
PubChem Substance ID	14958958, 29310996, 47805539, 48253958, 79472504, 103288150, 103955160, 103972682, 104378696, 134351767, 135089410, 135650486, 233223492
Target and Pathway
Target(s)	Cholecystokinin receptor type A	Target Info	Inhibitor	[551292]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Insulin secretion
	Pancreatic secretion
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543272	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 881).
Ref 551292	C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCKB/gastrin receptor antagonists, Bioorg. Med. Chem. Lett. 5(24):3023-3026 (1995).

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Drug Information