Drug General Information
Drug ID	D04BYL
Former ID	DNC010273
Drug Name	6-fluoronorepinehprine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530478]
Structure		Download 2D MOL 3D MOL
Formula	C8H10FNO3
Canonical SMILES	C1=CC(=C(C(=C1C(CN)O)F)O)O
InChI	1S/C8H10FNO3/c9-7-4(6(12)3-10)1-2-5(11)8(7)13/h1-2,6,11-13H,3,10H2/t6-/m0/s1
InChIKey	FOTRTWXNJQSQJS-LURJTMIESA-N
PubChem Compound ID	10352428
Target and Pathway
Target(s)	Alpha-1B adrenergic receptor	Target Info	Inhibitor	[530478]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
Pathway Interaction Database	LPA receptor mediated events
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	AMPK Signaling
References
Ref 530478	Bioorg Med Chem. 2009 Dec 1;17(23):7987-92. Epub 2009 Oct 13.Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.
Ref 530478	Bioorg Med Chem. 2009 Dec 1;17(23):7987-92. Epub 2009 Oct 13.Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.

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