Drug General Information
Drug ID	D04CON
Former ID	DIB015958
Drug Name	SL-89.0591
Indication	Prostate disease [ICD10:N42.9]		Discontinued in Phase 2	[545536]
Company	Synthelabo
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1(c2cc(ccc2OC)Cl)CCN(CC1)CCCNc1nc(C(=O)N)ccn1
CAS Number	CAS 194674-19-6
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Modulator	[525538]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 545536	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003628)
Ref 525538	Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity. Eur J Pharmacol. 1999 May 28;373(1):51-62.

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