Drug Information

Drug General Information
Drug ID
D04CPW
Former ID
DNC009291
Drug Name
N-(4-Propylaminobutyl)-4-biphenylcarboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529734]
Structure
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2D MOL

3D MOL
Formula
C20H26N2O
Canonical SMILES
CCCNCCCCNC(=O)C1=CC=C(C=C1)C2=CC=CC=C2
InChI
1S/C20H26N2O/c1-2-14-21-15-6-7-16-22-20(23)19-12-10-18(11-13-19)17-8-4-3-5-9-17/h3-5,8-13,21H,2,6-7,14-16H2,1H3,(H,22,23)
InChIKey
QAAKBUYWNXINKR-UHFFFAOYSA-N
PubChem Compound ID
25139331
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [529734]
Dopamine D1 receptor Target Info Inhibitor [529734]
D(4) dopamine receptor Target Info Inhibitor [529734]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCRs, Other
References
Ref 529734J Med Chem. 2008 Nov 13;51(21):6829-38. Epub 2008 Oct 4.Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Ref 529734J Med Chem. 2008 Nov 13;51(21):6829-38. Epub 2008 Oct 4.Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.

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