Drug Information

Drug General Information
Drug ID
D04CSZ
Former ID
DAP000876
Drug Name
Menthol
Synonyms
Hexahydrothymol; Levomenthol; Levomentholum; Menthacamphor; Menthomenthol; Neoisomenthol; Racementhol; Racementholum; Racementol; Headache crystals; Menthol natural; Menthol racemic; Menthol racemique; Menthol racemique [French]; Menthol solution; Menthyl alcohol; Peppermint camphor; Racemic menthol; Robitussin Cough Drops; M0321; M0545; D-Menthol; D-Neomenthol; Dl-Menthol; Fisherman's friend lozenges; L-Menthol; Levomenthol [INN:BAN]; Levomentholum [INN-Latin]; Menthol (USP); Menthol (VAN); Menthol natural, brazilian; NOOLISFMXDJSKH-KXUCPTDWBX; Rac-Menthol; Racementhol [INN:BAN]; Racementholum [INN-Latin]; Racementol [INN-Spanish]; Tra-kill tracheal mite killer; D,l-Menthol; Dl-Menthol (JP15); Fisherman's friendlozenges (TN); L-Menthol (JP15); L-Menthol (TN); L-Menthol (natural); Dl-3-p-Menthanol; P-Menthan-3-ol; RACEMIC MENTHOL U.S.P.; U.S.P. Menthol; D-(-)-Menthol; D-p-Menthan-3-ol; L-(-)-Menthol; Menthol, (1alpha,2beta,5alpha)-Isomer; Cis-1 ,3-trans-1,4-(+-)-menthol; Cis-1,3-trans-1,4-(+-)-menthol; (+)-Neo-menthol; (+)-p-Menthan-3-ol; (+-)-(1R*,3R*,4S*)-Menthol; (+-)-Menthol; (+/-)-Menthol; (+/-)-p-Menthan-3-ol; (-)-(1R,3R,4S)-Menthol; (-)-Menthyl alcohol; (-)-menthol; (-)-p-Menthan-3-ol; (-)-trans-p-Menthan-cis-ol; (1R)-(-)-Menthol; (1R,2S,5R)-Menthol; (1R,3R,4S)-(-)-MENTHOL; (1S, 2S, 5R)-(+)-Neomenthol; (1S,2R,5R)-(+)-Isomenthol; (1S,2R,5S)-(+)-Menthol; (1S,2R,5S)-Menthol; (1r,2s,5r)-(-)-menthol; (L)-MENTHOL; (R)-(-)-Menthol; 2-Isopropyl-5-methylcyclohexanol; 3-p-Menthol; 4-Isopropyl-1-methylcyclohexan-3-ol; 5-Methyl-2-(1-methylethyl)-cyclohexanol; 5-Methyl-2-(1-methylethyl)cyclohexanol; 5-methyl-2-(propan-2-yl)cyclohexanol; 5-methyl-2-propan-2-ylcyclohexan-1-ol
Drug Type
Small molecular drug
Indication Throat irritation [ICD9: 478.29; ICD10:J39.2] Approved [538582], [539598]
Therapeutic Class
Antipruritics
Structure
Download
2D MOL

3D MOL
Formula
C10H20O
InChI
InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m0/s1
InChIKey
NOOLISFMXDJSKH-AEJSXWLSSA-N
CAS Number
CAS 2216-51-5
PubChem Compound ID
165675
PubChem Substance ID
10664240, 12055913, 15388629, 24853440, 46239658, 48420130, 57350830, 75929472, 83549269, 87572824, 91691148, 103067196, 103077027, 113456940, 117556867, 124765985, 124955140, 125332761, 128732142, 131305826, 132563800, 134972992, 135043092, 135650579, 136904077, 137255636, 143046433, 144208241, 152248194, 160687409, 162242944, 163772994, 170474419, 175269391, 179694062, 198960312, 223388335, 223702533, 225165383, 226834155, 249822667, 250139819
ChEBI ID
ChEBI:15409
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Activator [537080]
TRPM8 protein Target Info Activator [537080]
KEGG Pathway Inflammatory mediator regulation of TRP channelshsa04750:Inflammatory mediator regulation of TRP channels
Reactome TRP channelsR-HSA-3295583:TRP channels
References
Ref 538582FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022029.
Ref 539598(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2471).
Ref 537080TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10. Epub 2009 Feb 13.

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