Drug General Information
Drug ID	D04CTN
Former ID	DNC012119
Drug Name	3-(1-Propyl-pyrrolidin-3-yl)-phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551334]
Structure		Download 2D MOL 3D MOL
Formula	C13H19NO
Canonical SMILES	CCCN1CCC(C1)C2=CC(=CC=C2)O
InChI	1S/C13H19NO/c1-2-7-14-8-6-12(10-14)11-4-3-5-13(15)9-11/h3-5,9,12,15H,2,6-8,10H2,1H3
InChIKey	WPYVGSUSOOZONM-UHFFFAOYSA-N
PubChem Compound ID	11074524
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[551334]
	D(2) dopamine receptor	Target Info	Inhibitor	[551334]
	D(3) dopamine receptor	Target Info	Inhibitor	[551334]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04015:Rap1 signaling pathway
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 551334	Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997).
Ref 551334	Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997).

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