Drug General Information
Drug ID
D04DFX
Former ID
DNC011261
Drug Name
Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531200]
Structure
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2D MOL

3D MOL

Formula
C14H11Br2N3OS
Canonical SMILES
C1=CC(=CC(=C1)Br)C(=C2C=CC(=O)C(=C2)Br)NNC(=S)N
InChI
1S/C14H11Br2N3OS/c15-10-3-1-2-8(6-10)13(18-19-14(17)21)9-4-5-12(20)11(16)7-9/h1-7,18H,(H3,17,19,21)/b13-9+
InChIKey
NPYRRUVCJBHCQQ-UKTHLTGXSA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin L Target Info Inhibitor [531200]
Cathepsin B Target Info Inhibitor [531200]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 531200Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. Epub 2010 Sep 15.Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.
Ref 531200Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. Epub 2010 Sep 15.Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.

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