Drug Information

Drug General Information
Drug ID
D04DJS
Former ID
DNC000769
Drug Name
ICI 118,551
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540833]
Structure
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2D MOL

3D MOL
Formula
C17H27NO2
InChI
InChI=1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3/t13-,16-/m0/s1
InChIKey
VFIDUCMKNJIJTO-BBRMVZONSA-N
CAS Number
CAS 380610-27-5
PubChem Compound ID
5484725
PubChem Substance ID
11111300, 11113719, 11534312, 14897433, 39472375, 50066371, 53789610, 57364035, 57560472, 77328713, 113992923, 124880384, 134457175, 135061923, 135650367, 138462904, 162169307, 184587764, 196378113, 198952098, 233575615
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Antagonist [537716]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540833(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 543).
Ref 537716Selective beta 2-adrenoceptor antagonists: derivatives of ICI 118,551 and a binary aryloxypropanolamine. J Pharm Pharmacol. 1988 Nov;40(11):803-5.

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