Drug Information

Drug General Information
Drug ID
D04DLR
Former ID
DNC000704
Drug Name
GR55562
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538677]
Structure
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2D MOL

3D MOL
Formula
C23H25N3O2
InChI
InChI=1S/C23H25N3O2/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28)
InChIKey
ZAGAUUVCYGSPBP-UHFFFAOYSA-N
PubChem Compound ID
128018
PubChem Substance ID
6873879, 7979444, 10241928, 11113886, 14779848, 26752049, 29307163, 47957331, 48331993, 57342415, 78454065, 85209091, 85788308, 90341318, 103345430, 103956265, 104367148, 129873705, 134224715, 134339588, 134340064, 135650319, 229389507
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Antagonist [534909]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538677(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 113).
Ref 5349095-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br J Pharmacol. 1999 Oct;128(3):730-4.

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