Drug General Information
Drug ID	D04DMQ
Former ID	DIB010695
Drug Name	Fabesetron
Synonyms	FK-1052
Drug Type	Small molecular drug
Indication	Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1]		Discontinued in Phase 2	[544894]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C18H19N3O
Canonical SMILES	n12c(c(c3c2cccc3)C)CC[C@@H](C1=O)Cc1c(nc[nH]1)C.Cl
PubChem Compound ID	208947
Target and Pathway
Target(s)	5-hydroxytryptamine 4 receptor	Target Info	Modulator
	5-HT 3 receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT4 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome	Serotonin receptors
	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544894	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001434)

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