TTD | Drug: D04ENK

Drug General Information
Drug ID	D04ENK
Former ID	DNC001415
Drug Name	TCV-309
Drug Type	Small molecular drug
Indication	Septic shock [ICD9: 785.52; ICD10:A41.9]		Discontinued in Phase 2	[545100]
Structure		Download 2D MOL 3D MOL
Formula	C30H34BrN5O7
Canonical SMILES	CCC[N+]1=C(C=C(C=C1)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC<br />=C3C2)C4=CC=CC=C4)Br.[N+](=O)([O-])[O-]
InChI	1S/C30H33BrN4O4.NO3/c1-2-16-33-17-13-24(21-27(33)31)29(37)35(26-10-4-3-5-11-26)19-14-28(36)32-15-20-39-30(38)34-18-12-23-8-6-7-9-25(23)22-34;2-1(3)4/h3-11,13,17,21H,2,12,14-16,18-20,22H2,1H3;/q;-1/p+1
InChIKey	XBPVPWDSUWHDIC-UHFFFAOYSA-O
PubChem Compound ID	115231
PubChem Substance ID	29296756, 50068129, 57339066, 75256363, 104397907
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL5 Signaling Pathway
NetPath Pathway	Leptin Signaling Pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545100	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002130)

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Drug Information