Drug Information

Drug General Information
Drug ID
D04FBZ
Former ID
DNC000986
Drug Name
Nalorphine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539003]
Structure
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2D MOL

3D MOL
Formula
C19H21NO3
InChI
InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1
InChIKey
UIQMVEYFGZJHCZ-SSTWWWIQSA-N
CAS Number
CAS 62-67-9
PubChem Compound ID
5284595
PubChem Substance ID
13951, 7980069, 11039367, 14752213, 39317901, 48032744, 48416307, 49992725, 50113068, 50812766, 57359132, 96024935, 103575820, 134223574, 134339919, 134340260, 134971522, 135650682, 137225348, 139813950, 160846163, 162224662, 179293397, 198970701, 198994148, 223440477, 223893849, 226424364, 241108741, 246598408
SuperDrug ATC ID
V03AB02
SuperDrug CAS ID
cas=000062679
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [534939]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539003(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1629).
Ref 534939Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeys. Eur J Pharmacol. 1999 Nov 3;383(3):305-9.

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