Drug Information

Drug General Information
Drug ID
D04FNQ
Former ID
DCL000726
Drug Name
BIM23A760
Drug Type
Small molecular drug
Indication Carcinoid syndrome; Acromegaly [ICD9: 253; ICD10:E34.0, E22.0] Phase 2 [528145], [536738]
Company
Ipsen
Structure
Download
2D MOL

3D MOL
Formula
C16H15ClO6
Canonical SMILES
CC(=O)OC1=C(C(=C(C2=C1C=CC(=C2)Cl)OC(=O)C)OC)OC
InChI
1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(21-4)15(13)20-3/h5-7H,1-4H3
InChIKey
IFWMVQUGSGWCRP-UHFFFAOYSA-N
PubChem Compound ID
56237
PubChem Substance ID
8184582, 12013176, 14924758, 43114103, 47206584, 52307642, 57313830, 103212462, 103918264, 104309618, 128162082, 134338930, 134339224, 135014523, 137828745, 141541221, 144087478, 179151429, 184546868, 198960991, 223454446, 224898781, 226491780
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [528145]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 528145BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide. J Endocrinol Invest. 2005;28(11 Suppl International):21-7.
Ref 536738Emerging drugs for acromegaly. Expert Opin Emerg Drugs. 2008 Jun;13(2):273-93.
Ref 528145BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide. J Endocrinol Invest. 2005;28(11 Suppl International):21-7.

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