Drug Information

Drug General Information
Drug ID
D04FVU
Former ID
DAP000367
Drug Name
Palonosetron
Synonyms
Aloxi; Onicit; Palonosetron [INN]; Aloxi (TN); RS 25233-197; RS 25233-198; RS 25259-197; RS 25259-198; RS-25233-197; RS-25233-198; RS-25259-197; RS-25259-198; (3aR)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one; (S-(R*,R*))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one; 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one; 2-Qhbiqo
Drug Type
Small molecular drug
Indication Nausea; Vomiting [ICD9: 787, 787.0; ICD10:R11] Approved [536361], [542509]
Therapeutic Class
Antiemetics
Company
Eisai Inc
Structure
Download
2D MOL

3D MOL
Formula
C19H24N2O
InChI
InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1
InChIKey
CPZBLNMUGSZIPR-NVXWUHKLSA-N
CAS Number
CAS 119904-90-4
PubChem Compound ID
6337614
PubChem Substance ID
14775945, 16060983, 23947646, 42981470, 75937434, 96024423, 114468570, 124971526, 135105908, 136326677, 137241149, 140711236, 143386614, 152107168, 152258952, 160647797, 162176794, 163366311, 175268166, 179149852, 184664917, 184812355, 187051789, 224406629, 226395862, 238388367, 241033029, 247473592, 249807123, 249867953, 251916686, 251917925, 252110261, 252355666, 252818196
SuperDrug ATC ID
A04AA05
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Antagonist [537311]
KEGG Pathway Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542509(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7486).
Ref 537311Management of postoperative nausea and vomiting: focus on palonosetron. Ther Clin Risk Manag. 2009 Feb;5(1):21-34. Epub 2009 Mar 26.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.