Drug Information

Drug General Information
Drug ID
D04FYN
Former ID
DNC007067
Drug Name
Diethyl 2-((biphenyl-3-ylamino)methylene)malonate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528617]
Structure
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2D MOL

3D MOL
Formula
C20H21NO4
Canonical SMILES
CCOC(=O)C(=CNC1=CC=CC(=C1)C2=CC=CC=C2)C(=O)OCC
InChI
1S/C20H21NO4/c1-3-24-19(22)18(20(23)25-4-2)14-21-17-12-8-11-16(13-17)15-9-6-5-7-10-15/h5-14,21H,3-4H2,1-2H3
InChIKey
OIXUYKLSAZTIDZ-UHFFFAOYSA-N
PubChem Compound ID
16102645
Target and Pathway
Target(s) Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [528617]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 528617J Med Chem. 2007 Jan 25;50(2):186-91.Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.
Ref 528617J Med Chem. 2007 Jan 25;50(2):186-91.Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

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