Drug Information

Drug General Information
Drug ID
D04GSA
Former ID
DIB007397
Drug Name
DAU-6285
Drug Type
Small molecular drug
Indication Emesis [ICD9: 787; ICD10:R11] Terminated [539587], [545063]
Company
Boehringer Ingelheim Corp
Structure
Download
2D MOL

3D MOL
Formula
C17H21N3O4
InChI
InChI=1S/C17H21N3O4/c1-19-10-3-4-11(19)8-13(7-10)24-17(22)20-15-9-12(23-2)5-6-14(15)18-16(20)21/h5-6,9-11,13H,3-4,7-8H2,1-2H3,(H,18,21)
InChIKey
HKBNGEJJECJLOW-UHFFFAOYSA-N
CAS Number
CAS 123258-98-0
PubChem Compound ID
129928
PubChem Substance ID
14899828, 23920157, 29308649, 47434771, 47954377, 48105101, 48105102, 76848733, 85209602, 103921131, 104371612, 128072245, 135650161, 143164432, 229008187, 242105997
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539587(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 246).
Ref 545063Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002002)

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